Pathogenic Mechanisms and Implications for Personalized Treatment of Multiple Sclerosis

Abstract

Multiple Sclerosis (MS) is a chronic autoimmune and demyelinating disease that affects the central nervous system, leading to inflammation and progressive neurodegeneration. This study explores the underlying pathogenic mechanisms and their implications for the development of personalized therapies, focusing on interventions tailored to the molecular and immunological specificities of each patient. The methodology involves a narrative review of databases such as PubMed and SciELO, covering studies on T and B cell-mediated autoimmune responses and the importance of biomarkers in monitoring disease activity. The results indicate that immunomodulatory and immunosuppressive treatments can be effective when individually adjusted, considering genetic factors and immunological profile. Personalized therapy for MS appears promising, contributing to an optimized therapeutic response and a lower incidence of adverse effects.