NEUROLOGICAL IMPACTS OF COVID-19
MECHANISMS AND LONG-TERM EFFECTS IN RECOVERED PATIENTS
DOI:
https://doi.org/10.65013/rms.v1i1.10Keywords:
COVID-19, Neurological Manifestations, Nervous System DisordersAbstract
This study aims to investigate the neurological manifestations associated with COVID-19, focusing on the relationship between the virus and nervous system disorders. A literature review was conducted, analyzing articles published between 2019 and 2023 from the PubMed, Scielo, and LILACS databases. Inclusion and exclusion criteria were applied, selecting studies addressing neurological complications from SARS-CoV-2 infection, including encephalitis, neuropathy, and other dysfunctions. Results indicated that COVID-19 can lead to a wide range of neurological manifestations, varying in severity and frequency depending on individual patient factors. It was concluded that neurological monitoring is essential for patients exhibiting severe COVID-19 symptoms, highlighting the need for further research to understand the exact mechanisms of viral neuroinvasion and to develop appropriate intervention strategies.
References
ACAR, Turkan; ACAR, Bilgehan; ARAS, Yesim et al. Demographic characteristics and neurological comorbidity
of patients with COVID-19. Revista da Associação Médica Brasileira, v. 66, n. 2, p. 82–85, 2020. Disponível em:
https://www.scielo.br/j/ramb/a/hdNQ3hqQwcpcrH6WQBZgsHC/#. Acesso em: 08 de novembro de 2024.
ALVES, Emily; BEBER, Barbara. Self-perception of cognitive sequels in post-COVID-19 individuals. Dementia &
Neuropsychologia, v. 17, n. 1, p. 1-16, 2023. Disponível em:
https://www.scielo.br/j/dn/a/7RmZzz8McCXkxZgsb9JcTrM/?lang=en#. Acesso em: 07 de novembro de 2024.
COSTA, Andreia; PINTO, André. Manifestações Neurológicas e COVID-19. Acta Médica Portuguesa, v. 33, n.
13, p. 1-16, 2020. Disponível em:
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/14504. Acesso em: 07 de novembro de
2024.
CREMASCHI, Renata; BAHI, Carla; PAOLA, Angelo et al. Neurological symptoms and comorbidity profile of
hospitalized patients with COVID-19. Arquivos de Neuro-Psiquiatria, v. 81, n. 2, p. 146–154, 2023. Disponível
em: https://www.scielo.br/j/anp/a/vQYKfwDnpchLjnfVvHhcrPD/?lang=en#. Acesso em: 07 de novembro de 2024.
ESTEVAM, Guilherme; PEREIRA, Matheus; ROCHA, Richard et al. Efeitos da pandemia em cuidadores de
indivíduos com alterações neuropsicomotoras. Fisioterapia em Movimento, v. 35, n. 1, p. 1-7, 2022. Disponível
em: chromeextension://
efaidnbmnnnibpcajpcglclefindmkaj/https://www.scielo.br/j/fm/a/sWm3wGdgqLz75bmZ9mcsNjK/?for
mat=pdf&lang=pt. Acesso em: 07 de novembro de 2024.
FIANI, Brian; COVARRUBIAS, Claudia; DESAI, Aditi et al. A Contemporary Review of Neurological Sequelae of
COVID-19. Frontiers in Neurology, v. 11, n. 1, p. 1-11, 2020. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/32655489/. Acesso em: 08 de novembro de 2024.
LIMA, Nayane; COSTA, Caroline; REIS, Angela et al. Neurotropismo de SARS-CoV-2: Possíveis impactos da
COVID-19 em portadores de Esclerose Lateral Amiotrófica. Research, Society and Development, v. 10, n. 7,
e28310716441, 2021. Disponível em: https://rsdjournal.org/index.php/rsd/article/download/16441/14788/211121.
Acesso em: 08 de novembro de 2024.
MENDONÇA, Valder; OLIVEIRA, Amanda; MAIA, Isabelle et al. COVID-19 in the nervous system:
physiopathology and neurological manifestations. Arquivos de Neuro-Psiquiatria, v. 81, n. 08, p. 756–763, 2023.
Disponível em: https://pubmed.ncbi.nlm.nih.gov/37402400/. Acesso em: 07 de novembro de 2024.
PINEDA, Lina; ARIAS, Alejandra; ROJAS, Diana et al. Manifestaciones neurológicas por COVID-19. Reporte de
casos en Hospital Militar Central Bogotá, Colombia, y revisión de la literatura. Revista Medicina, v. 29, n. 1, p. 57-
76, 2021. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1365426. Acesso em: 08 de
novembro de 2024.
SILVA, Filipa; BUCUR, Alexei; ROSADO, Steeve et al. Neurological dysfunction associated with COVID-19.
Revista Brasileira de Terapia Intensiva, v. 33, n. 2, p. 1-11, 2021. Disponível em:
https://www.scielo.br/j/rbti/a/7WWDCtTKdw4KhJ9wLLHwTyh/#. Acesso em: 07 de novembro de 2024.
TAHER, Taher; SHEIKH, Anum; ANWAR, Farah et al. SARS-CoV-2: its potential neurological manifestations and
plausible mechanism: a review article. Acta Neurologica Belgica, v. 121, n. 2, p. 331–339, 2021. Disponível em:
https://pubmed.ncbi.nlm.nih.gov/33464546/. Acesso em: 08 de novembro de 2024.
VERMA, Kalyani; AMITABH; PRASAD, Dipti et al. Brain and COVID-19 Crosstalk: Pathophysiological and
Psychological Manifestations. ACS Chemical Neuroscience, v. 11, n. 20, p. 3194–3203, Spring 2020. Disponível
em: https://pubmed.ncbi.nlm.nih.gov/33006881/. Acesso em: 08 de novembro de 2024.
YAVARPOUR-BALI, Hanie; GHASEMI-KASMAN, Maryam. Update on neurological manifestations of COVID-
19. Life Sciences, v. 257, n. 1, p. 118063, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32652139/. Acesso
em: 08 de novembro de 2024.
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